|
KMID : 0378019740170121761
|
|
New Medical Journal
1974 Volume.17 No. 12 p.1761 ~ p.1766
|
|
|
Bone Metastases of Malignant melanoma
|
|
|
|
|
Abstract
|
|
|
Since March 1973 we have had experience of 2 cases of bone metastases from malignant melanoma arising from the skin of the leg at Severance Hospital, Yonsei University.
In case I, a 36 year old housewife was admitted with a hard mass, 6X6X4cm in size, on the dorso￢medial aspect of the left foot for 7 years and palpable left inguinal lymph nodes which had developed 9 months before admission. Since birth dark brownish pigmentation was present on the skin of the left lower leg from the toes up. X-ray study showed an increased soft tissue shadow on the dorsomedial
aspect of the left first metatarsal bone. The primary lesion on the left foot was excised radically and the left inguinal lymph nedes were dissected out. The tumor mass on the foot was brownish black colour, hard in consistency and adherent to the periosteum and extensor hallux longus tendon. The cut surface of the tumor mass revealed multiple well circumscrived partly brownish black discolorated areas with surrounding fibrous connective tissue. The dissected lymph node revealed the same findings. Chemotherapy was recommended but the patient was discharged against recommendation.
In case 2, a 53 year old man was admitted with severe bone pain on the left proximal tibia for 2 months and a palable left inguinal lymph node which developed 2 months before admission. About 3 years previously local excision of a nevus on the left posterior calf area was performed at a private clinic. X-ray study showed an osteolytic destructive lesion on the proximal metaphysis of the left tibia with osteoporotic change. Biopsy from the site of the left proximal metaphyseal region and left inguinal lymph node dissection was performed. The biopsy material revealed a somewhat friable dark brownish colored destructive lesion. The tumor mass and the metastasized lymph node revealed also -the same pathologic findings. On the 10th postoperative day, initial Cobalt radiation therapy was started. A total amount of 6000 rads of radiation therapy was given the left proximal tibia and also to the left inguinal region. During the radiation therapy a distant metastasis was found in the left posterior
aspect of the neck and therefore radiation was given to the neck also. This patient unfortunately deve￢loped left hemiplegia, which may probably have been from metastasis, during radiation treatment of 4500 rads.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|